The Science

Full Research Library

We didn't guess at what works — we started with the science. Here are the 25+ peer-reviewed studies that informed every ingredient in your PMS kit.

Mood & Emotional Balance

  1. Saffron for the management of premenstrual dysphoric disorder: a randomized controlled trialAdvances in Biomedical Research, 2020
  2. Effect of saffron on premenstrual syndrome and dysmenorrhea: a systematic review and meta-analysisKorean Journal of Family Medicine, 2025
  3. Crocus sativus L. (saffron) in the treatment of premenstrual syndrome: a double-blind, randomised, placebo-controlled trialBJOG, 2008
  4. affron® saffron extract improves mood in healthy adults: a double-blind, randomized, placebo-controlled trialComplementary Therapies in Medicine, 2017
  5. Effects of a saffron extract (affron®) on mood and general wellbeing: a randomized, double-blind, placebo-controlled trialJournal of Nutrition, 2025
  6. Efficacy of vitamin B-6 in the treatment of premenstrual syndrome: systematic reviewBMJ, 1999
  7. Effects of vitamin B6 on premenstrual syndrome: a systematic review and meta-analysisJournal of Chemical & Pharmaceutical Sciences, 2016
  8. Pyridoxine (vitamin B6) and the premenstrual syndrome: a randomized crossover trialJ. Royal College of General Practitioners, 1989
  9. The effects of magnesium supplementation on subjective anxiety and stress: a systematic reviewNutrients, 2017
  10. The efficacy of lemon balm (Melissa officinalis L.) on premenstrual syndrome and quality of life: a randomized controlled trialJournal of Herbal Medicine, 2016
  11. The effects of lemon balm on depression and anxiety in clinical trials: a systematic review and meta-analysisPhytotherapy Research, 2021
  12. Clinical efficacy and tolerability of lemon balm in psychological well-being: a reviewNutrients, 2024
  13. Effect of Melissa officinalis capsule on the intensity of premenstrual syndrome symptoms in high school girls: a double-blind, randomized, placebo-controlled trialNursing and Midwifery Studies, 2015

Cramps & Pain

  1. Magnesium and oral contraceptives in primary dysmenorrhea: a clinical comparisonCureus, 2022
  2. Therapeutic effects of magnesium in dysmenorrheaSchweiz. Rundschau für Medizin (Praxis), 1990
  3. Efficacy of oral ginger (Zingiber officinale) for dysmenorrhea: a systematic review and meta-analysisEvidence-Based Complementary and Alternative Medicine, 2016
  4. Efficacy of ginger for alleviating the symptoms of primary dysmenorrhea: a systematic review and meta-analysisPain Medicine, 2015
  5. Effect of treatment with ginger on the severity of premenstrual syndrome symptoms: a randomized controlled trialISRN Obstetrics and Gynecology, 2014
  6. Effect of Zingiber officinale (ginger) rhizomes on pain relief in primary dysmenorrhea: a placebo randomized trialBMC Complementary and Alternative Medicine, 2012

Bloating & Water Retention

  1. Magnesium supplementation alleviates premenstrual symptoms of fluid retention: a randomized, double-blind, placebo-controlled crossover studyJournal of Women's Health, 1998
  2. The diuretic effect in human subjects of an extract of Taraxacum officinale folium over a single dayJournal of Alternative and Complementary Medicine, 2009

Fatigue & Energy

  1. The effects of lemon balm on menstrual bleeding and the systemic manifestations of dysmenorrhea: a double-blind randomized controlled trialIranian Journal of Pharmaceutical Research, 2018
  2. Taurine antioxidant activity: a controlled clinical trial in womenNutrition, 2022
  3. The effects of an oral taurine dose on endurance performance in humans: a meta-analysisSports Medicine, 2018

Why This Formula Works

  1. Magnesium citrate found more bioavailable than other magnesium preparations: a randomised, double-blind studyMagnesium Research, 2003
  2. Evaluating the effect of magnesium and magnesium plus vitamin B6 on the severity of premenstrual syndromeJournal of Caring Sciences, 2012
  3. A synergistic effect of magnesium plus vitamin B6 for anxiety-related premenstrual symptoms: a randomized, double-blind, crossover studyJournal of Women's Health & Gender-Based Medicine, 2000

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Studies reflect research on individual ingredients and are provided for transparency.

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